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Acknowledgements We are grateful to the animal facilities (IBPS), Camille Robert and Paris Vision Institute AAV production facility for viral production and purification

Additional measures, such as the Protecting American Lungs and Reversing the Youth Tobacco Epidemic Act of 2020 (HR 2339), seek to curb youth nicotine addiction by expanding FDA regulations to cover e-cigarettes and imposing several restrictions on tobacco (including e-cigarette) products and sales [77, 93]

Switching to other flavoured e-cigarettes or menthol-flavoured pod systems were the top two changes for both exclusive e-cigarette users and dual users