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Taken together, understanding the contributions of immune and metabolic parameters to tumour development is crucial for improving the predictive value and therapeutic strategies for p53 mutant lung cancers

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p53 has also been described as a key player in the induction of senescence since, in concert with PI3K/AKT/mTOR signaling, it can drive the cells to an irreversible cell cycle arrest that counteracts oncogenic transformation [82]

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