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There has been considerable interest in the development of nonpeptidic ligands for GLP-1R as leads with improved bioavailability (Chen et al., 2007

Notably, a seven-day regimen of intraperitoneal administration of the GLP-1 analog Exendin-4 has been observed to attenuate anxiety-like behaviors in mice undergoing heroin withdrawal

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinsons and Alzheimers disease brains

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