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Description
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Etiologies include syndromic disorders (Prader-Willi, Bardet-Biedl and Alstrm syndromes), monogenic defects of appetite-regulating pathways - most significantly melanocortin-4-receptor (MC4R) deficiency, but also leptin receptor (LEPR), pro-opiomelanocortin (POMC), and secondary hypothalamic injury, most commonly craniopharyngiomas

Purpose of Review Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are used by increasing numbers of patients, but may adversely affect the safety of endoscopic procedures, due to their association with decreased gastrointestinal motility

GLP-1 medications begin reducing appetite within days, but meaningful weight loss typically emerges over weeks and months
