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PMOS is a common endocrine and metabolic condition Raised body mass index (BMI) reduces fertility by causing hormonal imbalances, which can disrupt ovulation in women, Clare Thompson, MBBS, BSc, nMRCGP, General Practitioner at the Cadogan Clinic, where she leads the Weight Management Service, who was not involved in the study, explained to Medical News Today

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4.5.2 Early pregnancy exposure: risk characterization under limited data Existing registry, cohort, and systematic-review data have not identified a stable pattern of major structural malformations after brief early-pregnancy exposure to GLP-1RAs, but the exposed human evidence base remains limited and heterogeneous