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Guidelines have evolved considerably from routine medication cessation in 2023 to GLP-1 RA continuation with individualised risk assessment in 20242025, illustrating increasing acknowledgment that certain theoretical risks may be underestimated

But even with excellent lifestyle habits, many patients experience some weight regain after discontinuation

Suppressed macrophage infiltration followed by reduced macrophage foam cell formation by active forms of GLP-1 and GIP was demonstrated by Nagashima M, et al