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A., & Roth, B
Featuring Akkermansia, known for promoting metabolic balance and supporting weight management efforts
Potential mechanisms worth looking into are sleep-promoting GABAergic activity, augmenting antioxidant capacity, hormones such as cortisol and testosterone
Versus resmetirom (the approved MASH drug) Resmetirom is mechanistically orthogonal: it acts directly in the liver via thyroid hormone receptor- to increase hepatic fat oxidation, and its approval was based on biopsy endpoints in MASH with fibrosis not on weight loss
