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Retatrutide achieved approximately 24.2% mean weight loss in just 48 weeks compared to CagriSemas 22.7% over 68 weeks and 23% over 84 weeks

That weight loss is largely from fat mass, including a disproportionately large reduction in visceral abdominal fat and improvements in waist circumference

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Relatively greater weight loss has been seen in women and in people with a lower starting body weight
