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This residual weight loss corresponds approximately to a 45% reduction in body weight relative to the baseline (at initial weight loss of 1520%) Well, this on the borderline of clinically significant weight loss and probably not enough to sustation CV and other positive effects The best strategy appears to be long term GLP-1 treatment perahps with in lower maintaining doses #obesity #glp1 #treatmentcessation #weightregain #glp1receptoragonist Q

Randomly assigned groups received one of three doses 3 mg, 12 mg, 36 mg or a placebo once a day for 40 weeks

Other oral compounds like CT-996 / RG 6652 showed a clinically meaningful weight reduction of 6-7% in four weeks among participants without T2D, and GSBR-1290 has demonstrated favourable safety, tolerability and efficacy results

, GLP-1