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A comprehensive meta-analysis of eight GLP-1 RA CVOTs revealed several critical findings: 14% reduction in major adverse cardiovascular events (MACE: cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke) [3] 13% reduction in cardiovascular death [3] 10% reduction in all-cause mortality [3] 11% reduction in hospitalization for heart failure [3] Post-hoc analyzes from LEADER and SUSTAIN-6 revealed that cardiovascular benefits extended across the spectrum of body mass index categories, indicating efficacy regardless of baseline weight [2]

The Butsch data showed deficiencies roughly doubling between the 6- and 12-month marks

And for others, it can help them taper off a GLP-1 while reducing their risk of rebound weight gain especially if they pair it with other lifestyle changes like regular physical activity and a nutritious diet