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Despite this, GLP-1RA also exert a significant benefit on HF which suggest their use when SGLT-2 inhibitors are contraindicated or not tolerated
Mean change in body weight from baseline to Week 52 was a secondary endpoint
A post-hoc analysis of the SURMOUNT-4 trial found that only 28 percent of participants maintained 90 percent or more of their weight loss after discontinuation, while 72 percent regained more than 10 percent of the weight they had lost
