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Here, posttranslational processing of the 160 amino acid proglucagon by prohormone convertase 1/3 (PC1/3) yields active peptides glicentin, glucagon-like peptide 1 (GLP-1), intervening peptide 2 (IP2), and glucagon-like peptide 2 (GLP-2) (Mojsov et al., 1986