tirzepatide dose escalation reddit TrimRX Tirzepatide: A Promising Drug for

Tirzepatide vs Semaglutide A 2025 NEJM study found: Tirzepatide: 20.2% loss Semaglutide 2.4 mg: 13.7% loss Tirzepatide produced 47% greater relative weight loss Source: Aronne et al., 2025

Patients who had recently taken weight loss drugs, investigational drugs, and/or specific glycemic drugs were also excluded, depending on the agentthe ones I saw pop up most often were other GLP-1 agonists, other insulins, DPP-4 inhibitors (such as Januvia), and pramlintide

Just a conversation about what might actually help

All attention is now on the Lp(a)HORIZON outcomes study, which, if positive, would not only be transformative for patients but also validate Lp(a) as a causal target in ASCVD, though the field is intensifying with several RNA-based competitors also in late-stage development