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Hepatic impairment also appears to have limited effect on tirzepatide pharmacokinetics

Heres how: Drink water throughout the day to stay hydrated Rinse your mouth after vomiting to neutralize stomach acid Use a fluoride toothpaste and mouthwash to strengthen enamel Chew sugar-free gum to stimulate saliva production Avoid acidic and sugary snacks that can damage teeth Frequent dental visits are critical
Celsa C, Pennisi G, Tulone A, et al

When diabetes is induced via streptozotocin (STZ) treatment in F344/DuCrj-DPP4-deficient rats, onset of hyperglycemia was delayed, but KO rats showed impaired creatinine clearance and more severe dyslipidemia, which might be caused by a dysregulated expression of factors involved in steroid and lipid metabolism (52, 53)
