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The medication can be quite disruptive to the digestive system initially, and some people have anxiety about the physical process of injection, too

Findings This cohort study of 185 066 individuals prescribed treatment with GLP-1 RAs revealed an association with slightly higher risk of developing incident DR but a similar incidence of NAION and fewer serious DR-associated complications, including new-onset blindness

Gerstein et al, 2019)

Tirzepatide Is Sufficient (Stay Put) If: You're close to your target weight: If tirzepatide has gotten you 8090% of the way to your goal, switching drugs mid-course introduces titration disruption and new side effects for a marginal numerical gain