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Expected 12-month results include 15 to 20% body weight loss (65 to 100+ pounds for a 400-pound person), 6 to 10 inch waist circumference reduction, transformative improvement in daily functional capacity, and resolution or significant improvement of multiple obesity-related conditions

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Acetic acid and butyric acid in SCFAs can activate GPR41 and GPR43 and inhibit histone deacetylase activity to exert anti-inflammatory effects [171]

The main gap is the absence of dietitian access , which means the behavioral and nutritional support side of the program relies on provider consultations rather than dedicated nutrition professionals