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[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Meissner WG, Remy P, Giordana C, Maltte D, Derkinderen P, Houto JL, et al

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"The results with semaglutide alone are encouraging and suggest a potential new treatment option for a group of patients who previously had very few." The Phase II trial followed about 700 adults with biopsy-confirmed MASH and moderate to advanced liver scarring, including participants who had already developed early cirrhosis

Given that PKC and TRPM5 are downstream effectors of Gq signalling in beta cells, our next step involved determining whether the PKC inhibitor (calphostin C) and TRPM5 blocker (TPPO) suppress the triagonist-induced increase in GSIS