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Author Contributions Concept and design: Katie Hughes, Yovan Ram Kurrun Sumaruth, Elmahi Mohammed, Vibhootee Sant Bakshsingh Acquisition, analysis, or interpretation of data: Katie Hughes, Yovan Ram Kurrun Sumaruth, Elmahi Mohammed, Vibhootee Sant Bakshsingh Drafting of the manuscript: Katie Hughes, Yovan Ram Kurrun Sumaruth, Elmahi Mohammed, Vibhootee Sant Bakshsingh Critical review of the manuscript for important intellectual content: Katie Hughes, Yovan Ram Kurrun Sumaruth, Elmahi Mohammed, Vibhootee Sant Bakshsingh References 1.Clinical potential of treatment with semaglutide in type 2 diabetes patients

[1] The oral formulation of semaglutide (Rybelsus) follows similar elimination kinetics to the injectable form despite the different route of administration

The proportion of participants achieving clinically meaningful weight loss thresholds at 48 weeks on the 12 mg dose: - 5% weight loss: 100% - 10% weight loss: 93% - 15% weight loss: 83% For comparison, placebo achieved 5% in 27%, 10% in 9%, and 15% in just 2%

PlexusDx patients on compounded semaglutide injections who integrate glutathione report improved symptom tolerance when dosing is coordinated correctly