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Initial approval of the first GLP-1RA, Exenatide, in 2006, followed by that of GLP-1RAs was swiftly followed up by randomized controlled trials (RCT) whose results revealed their role in treating T2D

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Diabetes Journals+1 Neuroinflammation / oxidative stress : GLP-1 agents appear to reduce microglial activation, lower inflammatory cytokines, improve antioxidant defenses in brain tissue

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