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Semaglutide and tirzepatide, originally developed to treat hyperglycemia in type 2 diabetes, have widely been hailed as the most effective weight loss drugs ever approved

Its sequence incorporates several non-natural amino acids, including Aib (alpha-aminoisobutyric acid) substitutions that confer protease resistance and extend half-life

The study will enrol a total of 45 patients who are obese or overweight with at least one weight-related comorbidity, have a pathological diagnosis of EC or atypical endometrial hyperplasia and have fertility desires

Hypoglycemia rates with tirzepatide were low when used without sulfonylureas or insulin, consistent with the glucose-dependent mechanism of action