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Each has trade-offs in terms of cost, convenience, and clinical supervision

Under alloimmune conditions, GLP-1R-expressing T cells are predominantly enriched within the exhausted CD8+ T cell population, where GLP-1R signaling functions as a negative costimulatory pathway that restrains excessive T-cell activation and tissue-damaging inflammation (104)

In a drug safety update, published on 28 January 2025, the MHRA cited findings of a recent European Medicines Agency (EMA) review of the available evidence for all GLP-1 and dual GIP/GLP-1 RAs, which concluded that data supports an association between the medicines and the potential risk of pulmonary aspiration during anaesthesia or deep sedation, owing to the delayed gastric emptying linked to these medicines

By addressing multiple risk factors, GLP-1 contributes to holistic wellness improvements beyond merely controlling diabetes