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Cardiovascular Effects Dose-dependent increases in heart rate were observed with retatrutide: Heart rate increases peaked at approximately 24 weeks Gradually declined thereafter while remaining elevated above baseline This pattern is similar to that observed with other GLP-1 receptor agonists[4] The clinical significance of these heart rate changes requires further evaluation in larger and longer-term studies

Firths logistic regression further demonstrated a good model fit (pseudo-R2 of 0.943), but the individual predictors (glucagon-like peptide-1 (GLP-1) type, age, and BMI) were not statistically significant