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More serious considerations the evaluating clinician will screen for include a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (GLP-1 medications carry a boxed warning for thyroid C-cell tumors based on animal studies), a history of pancreatitis, gallbladder disease, and severe gastrointestinal conditions

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A review of placebo-controlled trials of GLP-1RA and SGLT2-I in T2DM, with or without baseline MET therapy, suggests that both the classes are likely similar in efficacy, lowering A1c by 1%1.5%

This case report describes a patient who experienced significant resolution of her breast cancer-related lymphedema after initiation of a GLP-1RA for weight loss
