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Another ongoing trial will also investigate the effects of tirzepatide on CKD in patients with or without T2D, with a primary outcome of change in kidney oxygenation (TREASURE-CKD, NCT05536804) [71]

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372 In vitro, GLP-1 disrupts the ability of osteoblasts to survive and differentiate by triggering the activation of c-Fos, which is a proto-oncogene

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Emerging evidence indicates some GLP-1RAs can cross the blood-brain barrier and may have neuroprotective effects

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Secondly, elevated cAMP levels activate protein kinase A (PKA), which subsequently mediates the activation of AMP-activated protein kinase (AMPK)

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