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4 Clinical evidence in T2DM management A wide range of clinical trials and research have been performed to assess the effectiveness, safety, and tolerability of short-acting against long-acting GLP-1 analogues in the treatment and management of T2DM and obesity
Diabetes Obes Metab 2017;19:123341.PubMed 83
Analysis of specific topic This literature review was conducted following the PICO Framework, with details available in Supplementary material 1
As a result, the increased secondary BAs can activate TGR5, which increases L-cells and GLP-1 secretion by inhibiting the RhoA/ROCK pathway and inducing YAP activation [157, 203]
