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Additionally, weight loss reduces gallbladder motilitythe organ contracts less frequently and less completely, allowing bile stasis that facilitates stone development

the efficacy is sustained for a long period following a single injection while maintaining a good safety profile

The clinical trial numbers reflect this progression clearly

It is important to note that orlistat can reduce levothyroxine absorption, and the BNF recommends separating administration by at least 4 hours and monitoring thyroid function