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This was the basis for the FDA's August 2025 approval

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Compounds 47 and 48 (Figure 6), with IC 50 values of 0.83 and 0.43 M, respectively, which possess aryl-substituted piperazines with acetamide linkers, showed the best activity as DPP-4 inhibitors

When shedding happens, its usually telogen effluvium triggered by fast weight loss, not direct follicle damage
