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Target: Minimum 2-3 liters of water daily, more if youre training or its hot
The GLP-1 receptor agonist semaglutide reduces risks of kidney function loss, kidney failure, cardiovascular events, cardiovascular death and all-cause mortality in people with chronic kidney disease and type 2 diabetes

This additional mechanism also introduces the dysesthesia side effect not seen with tirzepatide

CrossRef Corneal confocal microscopy identifies early and definite diabetic cardiac autonomic neuropathy Shazli Azmi, Maryam Ferdousi, Alise Kalteniece, Ioannis N Petropoulos, Uazman Alam, Georgios Ponirakis, Omar Asghar, Andrew Marshall, Andrew JM Boulton, Nathan Efron, Rayaz A Malik Diabetes Research and Clinical Practice.2025
