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Patient-Specific Variables Affecting Fatigue: Age-related metabolic changes and adaptation capacity Baseline fitness levels and cardiovascular health status Liver and kidney function efficiency Concurrent medical conditions and medication interactions Nutritional status and dietary adherence patterns Duration of Semaglutide-Related Fatigue: Timeline and Recovery Patterns Semaglutide-induced fatigue typically resolves within several weeks to a few months as physiological adaptation progresses and metabolic efficiency improves

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