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McKinsey research indicates 61% of GLP-1 patients seeking aesthetic treatment have lost 11-30% of their body weight, and rapid weight loss often does not allow sufficient time for the skin to remodel

In healthy physiology, there is a dynamic equilibrium between desensitization and resensitization that maintains overall receptor responsiveness despite continuous agonist presence

Approvable documentation includes: "Patient has BMI 34.2 (measured 3/15/2026, height 5'6", weight 211 lbs) and hypertension (documented BP 148/94 on two visits)

Populations were propensity matched (1:1) on various demographic and risk factors to balance baseline cohorts, according to the groups paper on the work in American Journal of Ophthalmology