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Clinical studies show dose-dependent effects on weight loss: Average weight loss at 5 mg per week: 7.5 kg in comparison to a placebo Average weight loss at 10 mg per week: 11.0 kg in comparison to a placebo Average weight loss at 15 mg per week: 11.5 kg in comparison to a placebo Participants were able to lose up to 21% of their body weight with the highest dosage (15 mg)

Persistent digestive symptoms or dehydration should still be discussed with a healthcare professional

Low-dose opioids may be considered in severe refractory cases under specialist supervision

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