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An LMN is typically not required for diabetic use

Most GLP-1 agonists (semaglutide, liraglutide, dulaglutide, tirzepatide) do not require dose adjustment for mild-to-moderate renal impairment, though caution is warranted in severe renal impairment

The winner may be the company that best balances efficacy, tolerability, supply, pricing, payer coverage, and patient persistence
