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Key variants in the GLP1R gene (such as rs6923761), GIPR gene (rs1800437), and FTO and MC4R genes shape how your body processes appetite signals and metabolizes fat

The STEP trials showed that adults taking semaglutide lost 9.2% to 17.4% of their body weight over 68 weeks, compared to 2.4% with placebo

Compounded versions, while sometimes well-intentioned, do not offer the same guarantees

Other Serious Concerns MedlinePlus reports several serious side effects that need medical attention: Pancreatitis symptoms: Severe stomach pain radiating to your back Kidney problems: Changes in urination, swelling Allergic reactions: Rash, itching, difficulty breathing Thyroid issues: Lump in your neck, hoarseness Who Should Not Take Semaglutide