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Retatrutide is currently in phase 3 development and has not received regulatory approval
GLP-1Rs are expressed in the hypothalamus, hippocampus, cortex, and brainstem, as well as limbic and reward-related circuits (47)
Its dual mechanism of action offers a more holistic approach to managing diseases like obesity and diabetes, as opposed to single-receptor agonists that only target one aspect of metabolic control
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