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As there is no meaningful expression of GLP-1 receptors on hepatocytes, the major effect of GLP-1 agonists on MASH is likely to be indirect and may be related to a reduction in calorie intake, body weight and insulin resistance, all of which would lead to reduced liver lipid accumulation and hepatic inflammation 7,8

In conclusion, tirzepatide increased blood pressure and sympathetic activity in hypertensive rats without cardiac protection, highlighting context-dependent cardiovascular actions

If a patient on a high dose of semaglutide cannot fill their prescription for a large injection pen, they may fear that they will have to go back to square one, the smallest starter dose, and lose months of progress

These options also support the reduced appetite that GLP-1 therapy creates, allowing smaller, nutrient-dense meals that sustain satiety longer