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The mechanism of action involves dual agonism at both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors

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Mechanism of Action: Tirzepatide vs Exendin-4-Based GLP-1 Agonists Understanding the mechanistic differences between tirzepatide and exendin-4-based therapies is essential for appreciating their distinct clinical profiles

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doi: 10.1530/ETJ-24-0079 80 HuangGLinYZhuG

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GIP receptor activation was historically thought to have limited therapeutic potential in type 2 diabetes, as the insulinotropic response to GIP is often impaired in affected individuals

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