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Description
For autoinjectors, the force of the injector hitting the skin activates the needle

Vigorous shaking creates mechanical stress that promotes aggregation, the clumping of peptide molecules that reduces potency

A statistically significant increase in thyroid C-cell adenomas was observed in male rats (0.5 mg/kg) and female rats (0.15 mg/kg), and a statistically significant increase in thyroid C-cell adenomas and carcinomas combined was observed in male and female rats at all doses examined

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