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If insomnia or other sleep problems persist or get worse despite these measures, contact your doctor so you can review next steps together

Body aches most commonly appear early, usually in the initial phase of Week 1 to 4 after starting or increasing the dose, and many patients show improvement in the adaptation phase by Week 4 to 8

People with previous GI conditions Individuals with a history of gastroparesis, irritable bowel syndrome, inflammatory bowel disease, or chronic nausea are among the strongest candidates for microdosing

Tirzepatide and semaglutide work similarly, but tirzepatide targets both GIP and GLP-1 receptors, while semaglutide primarily targets GLP-1 alone