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GIP (Glucose-Dependent Insulinotropic Polypeptide): Added with Tirzepatide, GIP co-activation enhances the glucose-lowering and fat-storage-reducing effects of GLP-1 activation

Thus, activation of brain-derived GLP-1 would be necessary for peripherally circulating GLP-1/GLP-1RAs to engage GLP-1Rs in regions such as the ACB or VTA

Weekly weigh-ins (same day, same time, same conditions) smooth out some of this noise, but even then, a single week without weight loss does not indicate a problem

The resulting hormonal imbalance can screw with your reproductive cycle, specifically the normal development of egg follicles, and leave you with a bunch of tiny fluid sacs (hence, polycystic)