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Work from their labs and others led to the development of novel therapeutics to control insulin secretion in Type 2 diabetes based on understanding the action of GLP1 and its metabolism by the enzyme, DPP4, leading directly to the development of the DPP-4 inhibitors for diabetes therapy

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However, Despite glucagon-like peptide 1 agonists GLP1 higher efficacy, higher cost makes them not cost-effective [40] in many healthcare systems