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[ref] A 2025 study showed that patients with RLS had higher serum IL-13 (inflammatory cytokine) levels and altered natural killer cell levels.[ref] The IL-13 connection is interesting, since IL-13 is elevated in asthma and allergies, tying back to altered histamine levels in the brain
Obtaining definitive proof of synapses would require systematic reconstruction using serial electron microscopy on a large population of enteroendocrine cells
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