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GLP-1 receptor agonists: Beyond their pancreatic effects

In extreme scenarios, brain function is markedly affected by the health of other organs, as illustrated by the presence of hepatic encephalopathy in patients with cirrhosis [247], and uremic encephalopathy in patients with declining kidney function [248]

Capsules (non-enteric coated), containing each of the GLP-1 analogues combined with the Axcess delivery formulation (66 mg chenodeoxycholic acid and 33 mg of propyl gallate) were introduced into the intestine after fasting overnight, and blood samples were taken via the saphenous vein for 6 hours thereafter, prior to feeding

To determine whether the spindle-shaped fibroblasts seen in Figure 4 were activated PSCs, we performed double-staining of -SMA and GLP-1R in an area showing fibrosis (Figures 5ad)