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RR 0.51, P<0.001), cerebrovascular disease (RR 0.50, P<0.001), and heart failure (RR 0.55, P<0.001)

Some sub-analyses of large clinical trials suggest that GLP-1RA and sodium-glucose cotransporter 2 inhibitor combination therapy may provide more significant reductions in heart failure hospitalization and renal composite events than each alone

it is a metabolic intervention that must be guided by functional and body composition outcomes

Adults aged 18 years (20 years in Taiwan) with a diagnosis of type 2 diabetes, HbA1c between 53 and 91 mmol/mol (inclusive) and treated with a stable daily dose of metformin were eligible for inclusion