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About 85% of Americans support legalizing medical marijuana, and it is estimated that at least several million Americans currently use it
The second-generation TPH inhibitors exclusively act on peripheral tissues [215]
The decision to initiate, titrate, or escalate dose still requires individualized assessment
Based on Phase 2 trial data (Jastreboff et al., NEJM , 2023), diarrhoea was reported in a meaningful proportion of participants treated with retatrutide, with incidence increasing in a dose-dependent manner
