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Experts say the results are promising, but more research is needed.

For example, an APOE 4 carrierwhose allele is consistently linked to higher LDL-C and coronary heart disease riskwho also carries the GLP1R rs6923761 A allele, which attenuates GLP-1-mediated glycaemic response, may warrant closer lipid monitoring and earlier adjunctive lipid-lowering therapy when treated with tirzepatide [106,107]
In clinical studies, participants lost an average of 15% to 18% of their initial body weight over 68 weeks, with significant losses occurring in the first three months

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