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In AS, inflammation reduces the mucus layer and disrupts tight junctions, desmosomes, and adherens junctions that regulate epithelial permeability [31]
Acid reflux is amplified GLP-1 medications worsen acid reflux because food sits in the stomach longer
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Mechanistically, L-tryptophan upregulated the expression of GLP-1related genes (e.g., Gcg and Pcsk1 ) in intestinal L cells, further promoting GLP-1 production (Jiang et al., 2024)
