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In this context, it has been demonstrated that treatments with either a GLP1/Estrogen (GLP1/E) conjugate, a unimolecular GLP1/GIP (gastric inhibitory peptide) dual agonist, or a GLP1/GIP/Glucagon triagonist, markedly reduced body weight and improved diabetic complications, including hyperinsulinemia, in preclinical models of obesity in males 33,34,35

In both in vitro cell lines and rats, curcumin increased glycemic control via increasing GLP-1 production

Gut Microbes (2014) 5(4):54451.10.4161/gmic.29331 12 ClavelTHallerD

Daily Dosing: Comparing Convenience and Compliance FDA-Approved Oral Tablets: Must be taken first thing in the morning on an empty stomach Take with only 4 ounces of water or less Wait 30 minutes before eating, drinking anything else, or taking other medications Timing and fasting window are critical for absorption Requires daily compliance Compounded ODT Formulations: Dissolve under the tongue or in the cheek Taken once daily Generally no food/water restrictions (though specific instructions vary) May be more convenient than swallowed tablets Still requires daily compliance Injectable GLP-1s: Administered once weekly at any time of day Can be taken with or without food No fasting period required More forgiving if you're slightly late with your dose Studies show that patient preferences often shift once they understand these requirements