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But its not considered a common side effect

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Individual Genetic and Biomarker Context Genetic variations in GLP-1 receptor signaling (such as GLP1R rs6923761) and gastrointestinal transit genes may influence how quickly your body adapts to semaglutide's effects on bowel function

Slower gastric emptying: Helps you feel full longer Reduces appetite and portion size Blunts blood sugar spikes after meals However, this same mechanism can also slow overall digestive transit if the gut isnt properly supported