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Dumping symptoms are often debilitating and emotionally distressing, and are associated with a substantial reduction in quality of life and subsequently may lead to considerable weight loss as a result of the patient avoiding food intake.5,79 Pathophysiology of Dumping Syndrome Upper gastrointestinal (GI) surgery can reduce gastric volume, remove the barrier function of the pylorus, or affect gastric motor function via vagal denervation

This timeline is slightly slower than tirzepatide at equivalent points in the dose escalation, but the endpoint results at maximum tolerated doses are closer than many people expect

Lasting transformation

British journal of anaesthesia , 126 (3), 567571