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Evidence indicates that ADA co-localizing with adenosine receptors on dendritic cells (master antigen-presenting cells, APCs, of the immune system) and interacts with DPP4/CD26 that is expressed on lymphocytes

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In the treatment of periodontitis, subantimicrobial doses (SD) of doxycycline have shown anti-collagenolytic, matrix metalloproteases (MMPs) degrading, and cytokine down-regulating actions